July 28, 2025
Image credit: Cristina Medina-Menéndez
07/30/2025
Research Article
Previous work has shown that neural stem cells (NSCs) and ependymal cells (ECs) are derived from radial glial cells. Using scRNA-seq, Jianqun Zheng, Yawen Chen, Weihong Song, Xi Chen and co-workers provide a detailed characterization of cell fate trajectories in the developing ventricular zone, identifying TFEB as a regulator of the NSC/EPC balance.
Image credit: pbio.3003318
Current Issue June 2025
07/29/2025
Research Article
The primary cilium dynamically assembles and disassembles while maintaining structural stability and tightly regulated length, but the mechanisms that control this remain unclear. Jovana Deretic, Elif Nur Firat-Karalar and co-authors show that the ciliopathy-linked protein CCDC66 regulates both cilium stability and length in epithelial cells via microtubules, actin and vesicular trafficking.
Image credit: pbio.3003313
07/29/2025
Research Article
How do humans navigate unfamiliar environments? Denis Lan, Laurence Hunt and Christopher Summerfield reveal that humans and deep meta-learning networks combine ‘vector-based’ and ‘transition-based’ strategies for flexible navigation in similar ways.
Image credit: pbio.3003296
07/29/2025
Research Article
How does cerebral blood perfusion map onto micro-, meso- and macro-scale brain structure? Using arterial spin labeling data from the Human Connectome Project, Asa Farahani, Bratislav Misic and colleagues provide a detailed characterization of cerebral blood perfusion in the human brain, providing insights into how it changes with age and in neurodegenerative disease.
Image credit: pbio.3003277
07/28/2025
Methods and Resources
The use of transcriptomic and metabolomic approaches to elucidate plant biosynthetic pathways is limited by the need for prior knowledge. Kumar Saurabh Singh, Justin van der Hooft, Marnix Medema and co-workers develop MEANtools, an unsupervised computational workflow that integrates multi-omics data to predict metabolic pathways by linking transcripts to metabolites.
Image credit: pbio.3003307
07/28/2025
Research Article
Age-related thymic decline impairs T-cell immunity and increases infection risk in the elderly. Abigail Morales-Sánchez, Avinash Bhandoola, Jennifer Cowan and co-authors show that enhancing thymic function in aged mice restores naïve T cells and improves immune responses, thus supporting thymic regeneration in aging.
Image credit: pbio.3003283
08/01/2025
Perspective
What happens when the greatest strengths of science – openness, humility, self-criticism and self-correction – are exploited for political gain? Brian Nosek calls for scientists to affirm the genuine application of those strengths as the source of its trustworthiness.
Image credit: Pixabay user Geralt
07/29/2025
Editorial
Cancer evolves through dynamic exchanges with its environment. This Editorial by Yibin Kang introduces a new Collection of articles that explore this tumor–environment crosstalk across temporal and spatial scales.
Image credit: Yujiao Han & Yibin Kang
07/28/2025
Perspective
Large-scale omics datasets from tumor samples are becoming ever easier to generate and analyze. This Perspective article looks at how multiomics data be leveraged to help patients in the clinic.
Image credit: PublicDomainPictures from Pixabay
07/24/2025
Perspective
This Perspective argues that better preclinical models, understanding of stromal heterogeneity and integration of tumor microenvironment assessments into drug development are needed to improve treatment efficacy.
Image credit: pbio.3003276
Recent technological advancements in omics have unveiled the mechanisms governing tumor progression across spatial and temporal scales. This collection reveals the complexities of the crosstalk between cancer cells and the tumor microenvironment.
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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August 26 - 30
Meet Senior Editor Richard Hodge (rhodge@plos.org)
September 9 - 12
Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)
September 16 - 19
Meet Editor in Chief Nonia Pariente (npariente@plos.org)
October 5 - 7
Meet Senior Editor Richard Hodge (rhodge@plos.org)
October 7 - 11
Meet Associate Editor Taylor Hart (thart@plos.org)
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