Finding the Right Questions: Exploratory Pathway Analysis to Enhance Biological Discovery in Large Datasets
This essay by Kelder and colleagues discusses the role of pathways for exploratory data analysis in present-day biology.
This essay by Kelder and colleagues discusses the role of pathways for exploratory data analysis in present-day biology.
This synopsis describes the study by Tang et al in which computational modeling and experimentation in a model system for network dynamics reveal how network phase relationships are temperature-compensated in terms of their underlying synaptic and intrinsic membrane currents.
A novel mechanism explains how exercise exerts its beneficial effects on energy balance through an effect at the level of the hypothalamus. Read more in this primer discussing research by Carvalheira and colleagues.
This synopsis explains the work by Kirmaier et al on how cross-species transmission of simian immunodeficiency virus from sooty mangabeys (SIVsm) into rhesus macaques, and subsequent emergence of pathogenic SIVmac, required adaptation to overcome restriction encoded by the macaque TRIM5 gene.
Highlighted in a synopsis, this study by Ally and colleagues uses genetic estimates of clone age in trembling aspen to demonstrate a significant decline in male sexual fitness with increasing age, showing that long-lived clonal organisms are vulnerable to aging.
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