Structural and biochemical analysis of the bacterial exonuclease RNase T by Yu-Yuan Hsiao, Hanna Yuan and colleagues reveals that it plays a role in DNA repair pathways, where it binds bulge, bubble and Y-structured DNA and trims the 3' ends of DNA strands. Read more in this Synopsis.
Using chemical genetics and a global comparative analysis of protein and lipid phosphorylation, Mathieu Brochet, Oliver Billker and colleagues have identified protein kinase G as the upstream regulator that induces the calcium signals required for Plasmodium to progress through its complex life cycle.
The new PLOS Data Policy will require all submitting authors to include a data availability statement as of March 1st. Read more about what this means and see the policy itself in this cross-PLOS Editorial from Theodora Bloom, Emma Ganley and Margaret Winker.
Gero Miesenböck and Dennis Kätzel have used optogenetic mapping of neuronal connectivity in the brain to show that mature circuits in the primary somatosensory cortex adapt to sensory deprivation by selectively altering specific network motifs. Read more in this Synopsis.
Image Credit: Flickr user jurvetson
How potentially devastating fungal effector proteins reach the cytoplasm of host plant cells is an unclear and much-debated area of research; this Unsolved Mystery by Benjamin Petre and Sophien Kamoun discusses recent conflicting findings and proposes an urgent need for novel experimental approaches.