Finding the Right Questions: Exploratory Pathway Analysis to Enhance Biological Discovery in Large Datasets
This essay by Kelder and colleagues discusses the role of pathways for exploratory data analysis in present-day biology.
- A Complete Developmental Sequence of a Drosophila Neuronal Lineage as Revealed by Twin-Spot MARCM
- The Perilipin Homologue, Lipid Storage Droplet 2, Regulates Sleep Homeostasis and Prevents Learning Impairments Following Sleep Loss
- IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition
- The Somatic Reproductive Tissues of C. elegans Promote Longevity through Steroid Hormone Signaling
- TRIM5 Suppresses Cross-Species Transmission of a Primate Immunodeficiency Virus and Selects for Emergence of Resistant Variants in the New Species
- Browse all recently published articles
Weekly Editors' Picks
Firing Hot, Firing Cold: How Poikilotherms Compensate for Temperature Swings
This synopsis describes the study by Tang et al in which computational modeling and experimentation in a model system for network dynamics reveal how network phase relationships are temperature-compensated in terms of their underlying synaptic and intrinsic membrane currents.
"Mens Sana In Corpore Sano": Exercise and Hypothalamic ER Stress
A novel mechanism explains how exercise exerts its beneficial effects on energy balance through an effect at the level of the hypothalamus. Read more in this primer discussing research by Carvalheira and colleagues.
TRIMming SIV Transmission between Species
This synopsis explains the work by Kirmaier et al on how cross-species transmission of simian immunodeficiency virus from sooty mangabeys (SIVsm) into rhesus macaques, and subsequent emergence of pathogenic SIVmac, required adaptation to overcome restriction encoded by the macaque TRIM5 gene.
We All Gotta Go Sometime
Highlighted in a synopsis, this study by Ally and colleagues uses genetic estimates of clone age in trembling aspen to demonstrate a significant decline in male sexual fitness with increasing age, showing that long-lived clonal organisms are vulnerable to aging.
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The Genographic Project is a five-year research partnership using cutting-edge genetic and computational technologies to analyze historical patterns in DNA from participants around the world to better understand human genetic roots.
