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Weekly Editors' Picks

Article-Level Metrics and the Evolution of Scientific Impact

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Metrics for evaluating papers and reputation in science have traditionally centered on the journal in a one-size-fits-all approach. Neylon and Wu offer their perspective on the richer and more accurate picture of scientific impact and relevance now possible with the advent of article-level metrics, such as comments, ratings, download and page view statistics, citations, and trackbacks from other websites, which more directly relate to individual articles.

 

Sly Represses Gene Expression in Sex Chromosomes

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A new synopsis explains a study by Burgoyne et al. in which small-interfering RNAs are used to disrupt the function of the more than 100 copies of the Sly gene on the mouse Y chromosome. This leads to defective sex chromosome repression during spermatid differentiation and, as a consequence, sperm malformations and near-sterility.

 

Migrating Brain Cells Stick Together

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This synopsis discusses a study by Köster and colleagues in which imaging cerebellar granule neurons in zebrafish embryos reveals a further role for Cadherin-2 in neurogenesis. It regulates cohesive and directional granule cell migration via intra-membranous Cadherin-2 relocalisation and centrosome stabilization.

 

University Public-Access Mandates Are Good for Science

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David Shulenburger offers his Perspective on how a new and better order to make scholarship available for free to all is emerging through deposit mandates such as those adopted by Harvard, MIT, and Kansas. Illustration: BioMed Central/Andrzej Krauze.

 

PLoS Collection on the Genomics of Emerging Infectious Disease

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A collection of essays, perspectives, and reviews, produced with support from Google.org, describes how genomics can revolutionize our understanding of emerging infectious disease. The collection has contributions from nearly all the PLoS Journals; PLoS Biology offers an introductory Editorial from Jonathan Eisen and Catriona MacCallum, a Perspective from W. Florian Fricke et al. on the role of genomics in biosecurity, and Google.org's Perspective from Rajesh Gupta et al. advocating an Infectious Disease Genomics Project. You can listen to an audio interview discussion of the issues raised by this collection.

 

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