Borislav Dejanovic, Guenter Schwarz and colleagues discover that gephyrin – the principal scaffolding protein at inhibitory synapses – needs to be modified with the hydrophobic palmitoyl group in order to cluster and to assemble functional synapses.
New Research by Noriaki Sasai, Eva Kutejova and James Briscoe demonstrates the importance of integrating FGF signalling with two perpendicular signalling pathways (Shh and BMP) to specify important cell types (Floor Plate and Neural Crest, respectively) during the development of the neural tube.
A large-scale field study, conducted by Joseph Jackson, Mike Begon and colleagues in naturally occurring vole populations, found that as they matured, the animals moved from resistance to tolerance of chronic parasite infection, with the immune transcription factor Gata3 flagging this shift to tolerance over time.
Image Credit: Flickr user Peter Trimming
TRACERx, a prospective study of patients with primary non-small cell lung cancer carried out by Miriam Jamal-Hanjani, Charles Swanton and colleagues, aims to map the genomic landscape of lung cancer by tracking tumour evolution from diagnosis to relapse.
Image Adapted From: TBWA\PARIS, France
A study by Sa Geng, Peter DeHoff and James Umen finds that a protein that controlled mating type in an ancestral unicellular alga evolved to control the development of visibly different sexes in its multicellular descendant Volvox. Read more in the Synopsis.