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Research Article

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

  • Tsuyoshi Hirota,

    Affiliations: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Jae Wook Lee,

    Affiliations: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America, Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America

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  • Warren G. Lewis,

    Affiliations: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Eric E. Zhang,

    Affiliations: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Ghislain Breton,

    Affiliation: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

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  • Xianzhong Liu,

    Affiliation: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Michael Garcia,

    Affiliation: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Eric C. Peters,

    Affiliation: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Jean-Pierre Etchegaray,

    Affiliation: Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • David Traver,

    Affiliation: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

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  • Peter G. Schultz,

    Affiliations: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America, Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America

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  • Steve A. Kay mail

    skay@ucsd.edu

    Affiliation: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

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  • Published: December 14, 2010
  • DOI: 10.1371/journal.pbio.1000559

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