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Research Article

Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

  • Jamie T. Bridgham,

    Affiliations: Howard Hughes Medical Institute, Eugene, Oregon, United States of America, Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America

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  • Geeta N. Eick,

    Affiliation: Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America

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  • Claire Larroux,

    Affiliation: School of Biological Sciences, University of Queensland, Brisbane, Australia

    Current address: Department of Earth & Environmental Sciences, Ludwig-Maximilians-University, Munich, Germany

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  • Kirti Deshpande,

    Affiliation: Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Michael J. Harms,

    Affiliation: Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America

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  • Marie E. A. Gauthier,

    Affiliation: School of Biological Sciences, University of Queensland, Brisbane, Australia

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  • Eric A. Ortlund,

    Affiliation: Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Bernard M. Degnan,

    Affiliation: School of Biological Sciences, University of Queensland, Brisbane, Australia

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  • Joseph W. Thornton mail

    joet@uoregon.edu

    Affiliations: Howard Hughes Medical Institute, Eugene, Oregon, United States of America, Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America

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  • Published: October 05, 2010
  • DOI: 10.1371/journal.pbio.1000497

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