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Research Article

A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation

  • Rodolphe Besancenot equal contributor,

    equal contributor Contributed equally to this work with: Rodolphe Besancenot, Ronan Chaligné

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • Ronan Chaligné equal contributor,

    equal contributor Contributed equally to this work with: Rodolphe Besancenot, Ronan Chaligné

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • Carole Tonetti,

    Affiliation: AP-HP, Université Paris XII, Laboratoire d'Hématologie, PRB Cellulothèque hématologie, Hôpital Henri Mondor, Créteil, France

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  • Florence Pasquier,

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • Caroline Marty,

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • Yann Lécluse,

    Affiliation: Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • William Vainchenker,

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • Stefan N. Constantinescu,

    Affiliation: Ludwig Institute for Cancer Research, Brussels, Belgium

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  • Stéphane Giraudier mail

    stephane.giraudier@hmn.aphp.fr

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, AP-HP, Université Paris XII, Laboratoire d'Hématologie, PRB Cellulothèque hématologie, Hôpital Henri Mondor, Créteil, France

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  • Published: September 07, 2010
  • DOI: 10.1371/journal.pbio.1000476

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