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Research Article

Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo

  • Leila M. Luheshi equal contributor,

    equal contributor Contributed equally to this work with: Leila M. Luheshi, Wolfgang Hoyer

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Wolfgang Hoyer equal contributor,

    equal contributor Contributed equally to this work with: Leila M. Luheshi, Wolfgang Hoyer

    Affiliations: Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden, Institute of Physical Biology, Heinrich-Heine-University, Dusseldorf, Germany

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  • Teresa Pereira de Barros,

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Iris van Dijk Härd,

    Affiliation: Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden

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  • Ann-Christin Brorsson,

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Bertil Macao,

    Affiliation: Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden

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  • Cecilia Persson,

    Affiliation: The Swedish NMR Centre, University of Gothenburg, Gothenburg, Sweden

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  • Damian C. Crowther,

    Affiliations: Department of Genetics, University of Cambridge, Cambridge, United Kingdom, Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

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  • David A. Lomas,

    Affiliation: Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

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  • Stefan Ståhl,

    Affiliation: School of Biotechnology, AlbaNova University Center, Royal Institute of Technology (KTH), Stockholm, Sweden

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  • Christopher M. Dobson mail,

    cmd44@cam.ac.uk (CMD); torleif.hard@molbio.slu.se (TH)

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Torleif Härd mail

    cmd44@cam.ac.uk (CMD); torleif.hard@molbio.slu.se (TH)

    Affiliations: The Swedish NMR Centre, University of Gothenburg, Gothenburg, Sweden, Department of Molecular Biology, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

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  • Published: March 16, 2010
  • DOI: 10.1371/journal.pbio.1000334

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