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Research Article

CDC5 Inhibits the Hyperphosphorylation of the Checkpoint Kinase Rad53, Leading to Checkpoint Adaptation

  • Genevieve M. Vidanes,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

    Current address: Conway Institute, University College Dublin, Belfield, Dublin, Ireland

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  • Frédéric D. Sweeney,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Sarah Galicia,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Stephanie Cheung,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • John P. Doyle,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Daniel Durocher,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • David P. Toczyski mail

    toczyski@cc.ucsf.edu

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Published: January 26, 2010
  • DOI: 10.1371/journal.pbio.1000286

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Research Article | published 26 Jan 2010 | PLOS Biology
doi:10.1371/journal.pbio.1000287