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Research Article

A Conserved CXXC Motif in CD3ε Is Critical for T Cell Development and TCR Signaling

  • Yibing Wang,

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America

    Current address: Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America

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  • Dean Becker,

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America

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  • Tibor Vass,

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America

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  • Janice White,

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America

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  • Philippa Marrack,

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America, Department of Biochemistry and Molecular Genetics, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, United States of America

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  • John W. Kappler mail

    kapplerj@njhealth.org

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America, Program in Biomolecular Structure, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, United States of America

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  • Published: December 01, 2009
  • DOI: 10.1371/journal.pbio.1000253

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