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Research Article

Polo-Like Kinase 1 Directs Assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF Complex to Initiate Cleavage Furrow Formation

  • Benjamin A. Wolfe,

    Affiliation: Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, United States of America

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  • Tohru Takaki,

    Affiliation: Cell Division and Aneuploidy Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, Hertfordshire, United Kingdom

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  • Mark Petronczki,

    Affiliation: Cell Division and Aneuploidy Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, Hertfordshire, United Kingdom

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  • Michael Glotzer mail

    mglotzer@uchicago.edu

    Affiliation: Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, United States of America

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  • Published: May 26, 2009
  • DOI: 10.1371/journal.pbio.1000110

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Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

Mark E. Burkard, John Maciejowski, VerĂ³nica Rodriguez-Bravo, Michael Repka, Drew M. Lowery, Karl R. Clauser, Chao Zhang, Kevan M. Shokat, Steven A. Carr, Michael B. Yaffe, Prasad V. Jallepalli
Research Article | published 26 May 2009 | PLOS Biology
doi:10.1371/journal.pbio.1000111