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Research Article

The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ

  • Keith I Pardee,

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada

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  • Xiaohui Xu,

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada, Midwest Center for Structural Genomics, University of Toronto, Toronto, Canada

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  • Jeff Reinking,

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada, Department of Biology, State University of New York at New Paltz, New Paltz, New York, United States of America

    ¤a Current address: Department of Structural and Chemical Biology, Ichah Medical Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Anja Schuetz,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Canada

    ¤b Current address: Protein Sample Production Facility, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Aiping Dong,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Canada

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  • Suya Liu,

    Affiliation: Department of Biochemistry, University of Western Ontario, London, Ontario, Canada

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  • Rongguang Zhang,

    Affiliation: Midwest Center for Structural Genomics, Argonne National Lab, Argonne, Illinois, United States of America

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  • Jens Tiefenbach,

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada

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  • Gilles Lajoie,

    Affiliation: Department of Biochemistry, University of Western Ontario, London, Ontario, Canada

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  • Alexander N Plotnikov,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Canada

    ¤b Current address: Protein Sample Production Facility, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Alexey Botchkarev,

    Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Canada

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  • Henry M Krause mail,

    To whom correspondence should be addressed. E-mail: aled.edwards@utoronto.ca (AE); h.krause@utoronto.ca (HMK)

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada

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  • Aled Edwards mail

    To whom correspondence should be addressed. E-mail: aled.edwards@utoronto.ca (AE); h.krause@utoronto.ca (HMK)

    Affiliations: Banting and Best Department of Medical Research, The Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada, Midwest Center for Structural Genomics, University of Toronto, Toronto, Canada, Structural Genomics Consortium, University of Toronto, Toronto, Canada

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  • Published: February 24, 2009
  • DOI: 10.1371/journal.pbio.1000043

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