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Research Article

Mutation of RNA Pol III Subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and Disrupts Zebrafish Digestive Development

  • Nelson S Yee equal contributor,

    equal contributor Contributed equally to this work with: Nelson S Yee, Weilong Gong

    Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    ¤a Current address: Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, Iowa, United States of America

    X
  • Weilong Gong equal contributor,

    equal contributor Contributed equally to this work with: Nelson S Yee, Weilong Gong

    Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Ying Huang,

    Affiliation: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

    ¤b Current address: College of Life Sciences, Nanjing Normal University, Nanjing, Peoples Republic of China

    X
  • Kristin Lorent,

    Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Amy C Dolan,

    Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Richard J Maraia,

    Affiliation: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Michael Pack mail

    To whom correspondence should be addressed. E-mail: mpack@mail.med.upenn.edu

    Affiliations: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Published: November 27, 2007
  • DOI: 10.1371/journal.pbio.0050312

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Diminished Activity of RNA Polymerase III Selectively Disrupts Tissues with the Most Actively Dividing Cells

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