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Research Article

Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor

  • Diego M. Presman,

    Affiliations: Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, Maryland, United States of America, Department of Biological Chemistry, School of Sciences (FCEN), University of Buenos Aires (UBA), Buenos Aires, Argentina, IFIBYNE-CONICET, School of Sciences (FCEN), University of Buenos Aires (UBA), Buenos Aires, Argentina

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  • M. Florencia Ogara equal contributor,

    equal contributor Contributed equally to this work with: M. Florencia Ogara, Martín Stortz

    Affiliations: Department of Biological Chemistry, School of Sciences (FCEN), University of Buenos Aires (UBA), Buenos Aires, Argentina, IFIBYNE-CONICET, School of Sciences (FCEN), University of Buenos Aires (UBA), Buenos Aires, Argentina

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  • Martín Stortz equal contributor,

    equal contributor Contributed equally to this work with: M. Florencia Ogara, Martín Stortz

    Affiliation: Department of Biological Chemistry, School of Sciences (FCEN), University of Buenos Aires (UBA), Buenos Aires, Argentina

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  • Lautaro D. Alvarez,

    Affiliation: Department of Organic Chemistry/UMYMFOR-CONICET, School of Sciences (FCEN), University of Buenos Aires (UBA), Buenos Aires, Argentina

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  • John R. Pooley,

    Affiliations: Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, Maryland, United States of America, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom

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  • R. Louis Schiltz,

    Affiliation: Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • Lars Grøntved,

    Affiliation: Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • Thomas A. Johnson,

    Affiliation: Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • Paul R. Mittelstadt,

    Affiliation: Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Jonathan D. Ashwell,

    Affiliation: Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Sundar Ganesan,

    Affiliation: Biological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, United States of America

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  • Gerardo Burton,

    Affiliation: Department of Organic Chemistry/UMYMFOR-CONICET, School of Sciences (FCEN), University of Buenos Aires (UBA), Buenos Aires, Argentina

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  • Valeria Levi,

    Affiliation: Department of Biological Chemistry, School of Sciences (FCEN), University of Buenos Aires (UBA), Buenos Aires, Argentina

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  • Gordon L. Hager mail,

    hagerg@exchange.nih.gov (GLH); apecci@qb.fcen.uba.ar (AP)

    Affiliation: Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • Adali Pecci mail

    hagerg@exchange.nih.gov (GLH); apecci@qb.fcen.uba.ar (AP)

    Affiliations: Department of Biological Chemistry, School of Sciences (FCEN), University of Buenos Aires (UBA), Buenos Aires, Argentina, IFIBYNE-CONICET, School of Sciences (FCEN), University of Buenos Aires (UBA), Buenos Aires, Argentina

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  • Published: March 18, 2014
  • DOI: 10.1371/journal.pbio.1001813

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doi:10.1371/journal.pbio.1001814