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Research Article

Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study

  • Christopher S. Carlson mail,

    ccarlson@fhcrc.org

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Tara C. Matise,

    Affiliation: Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

    X
  • Kari E. North,

    Affiliation: Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Christopher A. Haiman,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

    X
  • Megan D. Fesinmeyer,

    Affiliation: Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, Washington, United States of America

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  • Steven Buyske,

    Affiliation: Department of Statistics & Biostatistics, Rutgers University, Piscataway, New Jersey, United States of America

    X
  • Fredrick R. Schumacher,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

    X
  • Ulrike Peters,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Nora Franceschini,

    Affiliation: Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Marylyn D. Ritchie,

    Affiliation: Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • David J. Duggan,

    Affiliation: Translational Genomics Research Institute, Phoenix, Arizona, United States of America

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  • Kylee L. Spencer,

    Affiliation: Department of Biology & Environmental Science at Heidelberg University, Tiffin, Ohio, United States of America

    X
  • Logan Dumitrescu,

    Affiliation: Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Charles B. Eaton,

    Affiliation: Department of Family Medicine, Brown University, Pawtucket, Rhode Island, United States of America

    X
  • Fridtjof Thomas,

    Affiliation: Division of Biostatistics & Epidemiology, Department of Preventive Medicine, College of Medicine, The University of Tennessee Healthy Science Center, Memphis, Tennessee, United States of America

    X
  • Alicia Young,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Cara Carty,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Gerardo Heiss,

    Affiliation: Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Loic Le Marchand,

    Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

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  • Dana C. Crawford,

    Affiliation: Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Lucia A. Hindorff,

    Affiliation: Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Charles L. Kooperberg,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • for the PAGE Consortium

    Membership of the PAGE study is provided in the Acknowledgments.

    X
  • Published: September 17, 2013
  • DOI: 10.1371/journal.pbio.1001661

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