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Research Article

PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

  • Romy Walser,

    Affiliation: Department of Biomedicine, University of Basel, Basel, Switzerland

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  • John E. Burke,

    Affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Elena Gogvadze,

    Affiliation: Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Thomas Bohnacker,

    Affiliation: Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Xuxiao Zhang,

    Affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Daniel Hess,

    Affiliation: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

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  • Peter Küenzi,

    Affiliation: Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Michael Leitges,

    Affiliation: Biotechnology Centre, University of Oslo, Oslo, Norway

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  • Emilio Hirsch,

    Affiliation: Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy

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  • Roger L. Williams,

    Affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Muriel Laffargue,

    Affiliation: INSERM, UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France

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  • Matthias P. Wymann mail

    Matthias.Wymann@UniBas.CH

    Affiliation: Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Published: June 25, 2013
  • DOI: 10.1371/journal.pbio.1001587

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doi:10.1371/journal.pbio.1001594