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Research Article

PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance

  • Mian Cao equal contributor,

    equal contributor Contributed equally to this work with: Mian Cao, Zhuo Mao

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

    Current address: Department of Cell Biology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Zhuo Mao equal contributor,

    equal contributor Contributed equally to this work with: Mian Cao, Zhuo Mao

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

    X
  • Chuen Kam,

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

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  • Nan Xiao,

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

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  • Xiaoxing Cao,

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

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  • Chong Shen,

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

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  • Kenneth K. Y. Cheng,

    Affiliation: Department of Medicine and Department of Pharmacology & Pharmacy, University of Hong Kong, Hong Kong, China

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  • Aimin Xu,

    Affiliation: Department of Medicine and Department of Pharmacology & Pharmacy, University of Hong Kong, Hong Kong, China

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  • Kwong-Man Lee,

    Affiliation: Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China

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  • Liwen Jiang,

    Affiliation: School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China

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  • Jun Xia mail

    jxia@ust.hk

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

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  • Published: April 23, 2013
  • DOI: 10.1371/journal.pbio.1001541

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