Advertisement
Research Article

A Force-Activated Trip Switch Triggers Rapid Dissociation of a Colicin from Its Immunity Protein

  • Oliver E. Farrance,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

    X
  • Eleanore Hann,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

    X
  • Renata Kaminska,

    Affiliation: Department of Biochemistry, University of Oxford, Oxford, United Kingdom

    X
  • Nicholas G. Housden,

    Affiliation: Department of Biochemistry, University of Oxford, Oxford, United Kingdom

    X
  • Sasha R. Derrington,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

    X
  • Colin Kleanthous,

    Affiliation: Department of Biochemistry, University of Oxford, Oxford, United Kingdom

    X
  • Sheena E. Radford,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

    X
  • David J. Brockwell mail

    d.j.brockwell@leeds.ac.uk

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

    X
  • Published: February 19, 2013
  • DOI: 10.1371/journal.pbio.1001489

Media Coverage of this Article

Found additional news media or blog coverage for the article? Please let us know.

Linked Articles

A Small Force Remodels a Large Protein to Unleash Its Deadly Potential

Richard Robinson
Synopsis | published 19 Feb 2013 | PLOS Biology
doi:10.1371/journal.pbio.1001486