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Research Article

Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

  • Weiqin Lu equal contributor,

    equal contributor Contributed equally to this work with: Weiqin Lu, Yumin Hu

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Yumin Hu equal contributor,

    equal contributor Contributed equally to this work with: Weiqin Lu, Yumin Hu

    Affiliations: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China

    X
  • Gang Chen,

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Zhao Chen,

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Hui Zhang,

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Feng Wang,

    Affiliations: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China

    X
  • Li Feng,

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Helene Pelicano,

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Hua Wang,

    Affiliation: Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Michael J. Keating,

    Affiliation: Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Jinsong Liu,

    Affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Wallace McKeehan,

    Affiliation: Proteomics and Nanotechnology Laboratory, Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas, United States of America,

    X
  • Huamin Wang,

    Affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Yongde Luo,

    Affiliation: Proteomics and Nanotechnology Laboratory, Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas, United States of America,

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  • Peng Huang mail

    phuang@mdanderson.org

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Published: May 08, 2012
  • DOI: 10.1371/journal.pbio.1001326

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