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Research Article

Substantial Histone Reduction Modulates Genomewide Nucleosomal Occupancy and Global Transcriptional Output

  • Barbara Celona,

    Affiliation: San Raffaele University, Milan, Italy

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  • Assaf Weiner,

    Affiliations: School of Computer Science and Engineering, Hebrew University, Jerusalem, Israel, Alexander Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel

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  • Francesca Di Felice,

    Affiliation: Dipartimento di Biologia e Biotecnologie, Università di Roma La Sapienza, Rome, Italy

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  • Francesco M. Mancuso,

    Affiliation: IFOM-IEO Campus, Milan, Italy

    Current address: Bioinformatics Unit, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain

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  • Elisa Cesarini,

    Affiliation: Dipartimento di Biologia e Biotecnologie, Università di Roma La Sapienza, Rome, Italy

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  • Riccardo L. Rossi,

    Affiliation: Integrative Biology Program, Istituto Nazionale di Genetica Molecolare, Milan, Italy

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  • Lorna Gregory,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Dilair Baban,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Grazisa Rossetti,

    Affiliation: Integrative Biology Program, Istituto Nazionale di Genetica Molecolare, Milan, Italy

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  • Paolo Grianti,

    Affiliation: Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milan, Italy

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  • Massimiliano Pagani,

    Affiliation: Integrative Biology Program, Istituto Nazionale di Genetica Molecolare, Milan, Italy

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  • Tiziana Bonaldi,

    Affiliation: IFOM-IEO Campus, Milan, Italy

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  • Jiannis Ragoussis,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Nir Friedman,

    Affiliations: School of Computer Science and Engineering, Hebrew University, Jerusalem, Israel, Alexander Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel

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  • Giorgio Camilloni,

    Affiliations: Dipartimento di Biologia e Biotecnologie, Università di Roma La Sapienza, Rome, Italy, Istituto di Biologia e Patologia Molecolari, CNR, Rome, Italy

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  • Marco E. Bianchi mail,

    bianchi.marco@hsr.it (MEB); agresti.alessandra@hsr.it (AA)

    Affiliations: San Raffaele University, Milan, Italy, Division of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy

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  • Alessandra Agresti mail

    bianchi.marco@hsr.it (MEB); agresti.alessandra@hsr.it (AA)

    Affiliation: Division of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy

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  • Published: June 28, 2011
  • DOI: 10.1371/journal.pbio.1001086

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Linked Articles

Not All Genes Are Equal; Shortage of Histones Affects Some Genes More Than Others

Robin Mejia
Synopsis | published 28 Jun 2011 | PLOS Biology
doi:10.1371/journal.pbio.1001098