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Research Article

Rare Variants Create Synthetic Genome-Wide Associations

  • Samuel P. Dickson,

    Affiliations: Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America, Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America

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  • Kai Wang,

    Affiliation: Center for Applied Genomics, Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Ian Krantz,

    Affiliations: Center for Applied Genomics, Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Hakon Hakonarson,

    Affiliations: Center for Applied Genomics, Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • David B. Goldstein mail

    d.goldstein@duke.edu

    Affiliation: Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America

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  • Published: January 26, 2010
  • DOI: 10.1371/journal.pbio.1000294

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Common Disease, Multiple Rare (and Distant) Variants

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Synopsis | published 26 Jan 2010 | PLOS Biology
doi:10.1371/journal.pbio.1000293