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Research Article

Melanopsin as a Sleep Modulator: Circadian Gating of the Direct Effects of Light on Sleep and Altered Sleep Homeostasis in Opn4−/− Mice

  • Jessica W. Tsai,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Jens Hannibal,

    Affiliation: Department of Clinical Biochemistry, Rigshopitalet, Copenhagen, Denmark

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  • Grace Hagiwara,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Damien Colas,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Elisabeth Ruppert,

    Affiliation: Laboratory of Rhythms - CNRS UMR 7168/LC2, Louis Pasteur University and Department of Neurology - School of Medicine, Strasbourg, France

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  • Norman F. Ruby,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • H. Craig Heller,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Paul Franken mail,

    Paul.Franken@unil.ch (PF); Patrice.Bourgin@neurochem.u-strasbg.fr (PB)

    Affiliations: Department of Biology, Stanford University, Stanford, California, United States of America, Center for Integrative Genomics, University of Lausanne, 1015 Lausanne-Dorigny, Switzerland

    These authors are joint senior authors on this work.

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  • Patrice Bourgin mail

    Paul.Franken@unil.ch (PF); Patrice.Bourgin@neurochem.u-strasbg.fr (PB)

    Affiliations: Department of Biology, Stanford University, Stanford, California, United States of America, Laboratory of Rhythms - CNRS UMR 7168/LC2, Louis Pasteur University and Department of Neurology - School of Medicine, Strasbourg, France

    These authors are joint senior authors on this work.

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  • Published: June 09, 2009
  • DOI: 10.1371/journal.pbio.1000125

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Light, Sleep, and Circadian Rhythms: Together Again

Derk-Jan Dijk, Simon N. Archer
Primer | published 23 Jun 2009 | PLOS Biology
doi:10.1371/journal.pbio.1000145