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Research Article

A Point Mutation in the Hair Cell Nicotinic Cholinergic Receptor Prolongs Cochlear Inhibition and Enhances Noise Protection

  • Julian Taranda,

    Affiliations: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, United States of America

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  • Stéphane F Maison,

    Affiliation: Department of Otology and Laryngology, Harvard Medical School and Eaton–Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

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  • Jimena A Ballestero,

    Affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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  • Eleonora Katz,

    Affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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  • Jessica Savino,

    Affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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  • Douglas E Vetter,

    Affiliation: Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, United States of America

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  • Jim Boulter,

    Affiliation: Department of Psychiatry and Biobehavioral Sciences, Hatos Research Center for Neuropharmacology, Brain Research and Molecular Biology Institutes, University of California, Los Angeles, United States of America

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  • M. Charles Liberman,

    Affiliation: Department of Otology and Laryngology, Harvard Medical School and Eaton–Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

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  • Paul A Fuchs,

    Affiliation: Department of Otolaryngology, Head and Neck Surgery, and Center for Hearing and Balance, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • A. Belén Elgoyhen mail

    To whom correspondence should be addressed. E-mail: elgoyhen@dna.uba.ar

    Affiliations: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina, Departamento de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

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  • Published: January 20, 2009
  • DOI: 10.1371/journal.pbio.1000018

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