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Research Article

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

  • Laurent Kappeler equal contributor,

    equal contributor Contributed equally to this work with: Laurent Kappeler, Carlos De Magalhaes Filho

    Affiliation: INSERM U893, Hôpital Saint-Antoine, Paris, France

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  • Carlos De Magalhaes Filho equal contributor,

    equal contributor Contributed equally to this work with: Laurent Kappeler, Carlos De Magalhaes Filho

    Affiliations: INSERM U893, Hôpital Saint-Antoine, Paris, France, Université Pierre-et-Marie-Curie, Paris, France

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  • Joëlle Dupont,

    Affiliation: INRA, Nouzilly, France

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  • Patricia Leneuve,

    Affiliation: INSERM U893, Hôpital Saint-Antoine, Paris, France

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  • Pascale Cervera,

    Affiliation: Service d'Anatomopathologie, Hôpital Saint-Antoine, Paris, France

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  • Laurence Périn,

    Affiliation: INSERM U893, Hôpital Saint-Antoine, Paris, France

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  • Catherine Loudes,

    Affiliation: INSERM U549, Centre Paul Broca, Paris, France

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  • Annick Blaise,

    Affiliations: INSERM U893, Hôpital Saint-Antoine, Paris, France, Université Pierre-et-Marie-Curie, Paris, France

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  • Rüdiger Klein,

    Affiliation: Department of Molecular Neurobiology, Max-Planck Institute of Neurobiology, Munich-Martinsried, Germany

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  • Jacques Epelbaum,

    Affiliation: INSERM U549, Centre Paul Broca, Paris, France

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  • Yves Le Bouc,

    Affiliations: INSERM U893, Hôpital Saint-Antoine, Paris, France, Université Pierre-et-Marie-Curie, Paris, France

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  • Martin Holzenberger mail

    To whom correspondence should be addressed. E-mail: martin.holzenberger@inserm.fr

    Affiliation: INSERM U893, Hôpital Saint-Antoine, Paris, France

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  • Published: October 28, 2008
  • DOI: 10.1371/journal.pbio.0060254

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Brain Growth Receptors Control Lifespan

Richard Robinson
Synopsis | published 28 Oct 2008 | PLOS Biology
doi:10.1371/journal.pbio.0060274