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Research Article

A Specificity Map for the PDZ Domain Family

  • Raffi Tonikian equal contributor,

    equal contributor Contributed equally to this work with: Raffi Tonikian, Yingnan Zhang

    Affiliations: Terrence Donnelly Center for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Yingnan Zhang equal contributor,

    equal contributor Contributed equally to this work with: Raffi Tonikian, Yingnan Zhang

    Affiliation: Department of Protein Engineering, Genentech, South San Francisco, California, United States of America

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  • Stephen L Sazinsky,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Bridget Currell,

    Affiliation: Department of Molecular Biology, Genentech, South San Francisco, California, United States of America

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  • Jung-Hua Yeh,

    Affiliation: Department of Immunology, Genentech South San Francisco, California, United States of America

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  • Boris Reva,

    Affiliation: Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Heike A Held,

    Affiliation: Department of Protein Engineering, Genentech, South San Francisco, California, United States of America

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  • Brent A Appleton,

    Affiliation: Department of Protein Engineering, Genentech, South San Francisco, California, United States of America

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  • Marie Evangelista,

    Affiliation: Department of Molecular Biology, Genentech, South San Francisco, California, United States of America

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  • Yan Wu,

    Affiliation: Department of Antibody Engineering, Genentech, South San Francisco, California, United States of America

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  • Xiaofeng Xin,

    Affiliations: Terrence Donnelly Center for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Andrew C Chan,

    Affiliation: Department of Immunology, Genentech South San Francisco, California, United States of America

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  • Somasekar Seshagiri,

    Affiliation: Department of Molecular Biology, Genentech, South San Francisco, California, United States of America

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  • Laurence A Lasky,

    Affiliation: Department of Protein Engineering, Genentech, South San Francisco, California, United States of America

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  • Chris Sander,

    Affiliation: Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Charles Boone mail,

    To whom correspondence should be addressed. E-mail: sachdev.sidhu@utoronto.ca (SSS); gary.bader@utoronto.ca (GDB); charlie.boone@utoronto.ca (CB)

    Affiliations: Terrence Donnelly Center for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Gary D Bader mail,

    To whom correspondence should be addressed. E-mail: sachdev.sidhu@utoronto.ca (SSS); gary.bader@utoronto.ca (GDB); charlie.boone@utoronto.ca (CB)

    Affiliations: Terrence Donnelly Center for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    ¤ Current address: Terrence Donnelly Center for Cellular and Biomolecular Research and Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

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  • Sachdev S Sidhu mail

    To whom correspondence should be addressed. E-mail: sachdev.sidhu@utoronto.ca (SSS); gary.bader@utoronto.ca (GDB); charlie.boone@utoronto.ca (CB)

    Affiliation: Department of Protein Engineering, Genentech, South San Francisco, California, United States of America

    ¤ Current address: Terrence Donnelly Center for Cellular and Biomolecular Research and Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

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  • Published: September 30, 2008
  • DOI: 10.1371/journal.pbio.0060239

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