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Research Article

Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity

  • Shadmehr Demehri mail,

    To whom correspondence should be addressed. E-mail: Kopan@wustl.edu (RK); demehris@msnotes.wustl.edu (SD)

    Affiliations: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Zhenyi Liu,

    Affiliation: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Jonghyeob Lee,

    Affiliation: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    ¤ Current address: Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Meei-Hua Lin,

    Affiliation: Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Seth D Crosby,

    Affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Christopher J Roberts,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Perry W Grigsby,

    Affiliation: Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Jeffrey H Miner,

    Affiliation: Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Andrew G Farr,

    Affiliation: Department of Biological Structure and Department of Immunology, University of Washington, Seattle, Washington, United States of America

    X
  • Raphael Kopan mail

    To whom correspondence should be addressed. E-mail: Kopan@wustl.edu (RK); demehris@msnotes.wustl.edu (SD)

    Affiliations: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: May 27, 2008
  • DOI: 10.1371/journal.pbio.0060123

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Linked Articles

Correction: Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity

Shadmehr Demehri, Zhenyi Liu, Jonghyeob Lee, Meei-Hua Lin, Seth D Crosby, Christopher J Roberts, Perry W Grigsby, Jeffrey H Miner, Andrew G Farr, Raphael Kopan
Correction | published 29 Jul 2008 | PLOS Biology
doi:10.1371/journal.pbio.0060169

When Skin Damage Causes Death

Liza Gross
Synopsis | published 27 May 2008 | PLOS Biology
doi:10.1371/journal.pbio.0060133