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Research Article

Ablation of PGC-1β Results in Defective Mitochondrial Activity, Thermogenesis, Hepatic Function, and Cardiac Performance

  • Christopher J Lelliott equal contributor,

    equal contributor Contributed equally to this work with: Christopher J Lelliott, Gema Medina-Gomez

    Affiliations: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom, AstraZeneca R&D, Mölndal, Sweden

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  • Gema Medina-Gomez equal contributor,

    equal contributor Contributed equally to this work with: Christopher J Lelliott, Gema Medina-Gomez

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Natasa Petrovic,

    Affiliation: The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

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  • Adrienn Kis,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Helena M Feldmann,

    Affiliation: The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

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  • Mikael Bjursell,

    Affiliation: AstraZeneca R&D, Mölndal, Sweden

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  • Nadeene Parker,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Keira Curtis,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Mark Campbell,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Ping Hu,

    Affiliation: Division of Cardiology, University of Utah, Salt Lake City, Utah, United States of America

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  • Dongfang Zhang,

    Affiliation: Division of Cardiology, University of Utah, Salt Lake City, Utah, United States of America

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  • Sheldon E Litwin,

    Affiliation: Division of Cardiology, University of Utah, Salt Lake City, Utah, United States of America

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  • Vlad G Zaha,

    Affiliation: Division of Endocrinology, Metabolism, and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, United States of America

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  • Kimberly T Fountain,

    Affiliation: Division of Endocrinology, Metabolism, and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, United States of America

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  • Sihem Boudina,

    Affiliation: Division of Endocrinology, Metabolism, and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, United States of America

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  • Mercedes Jimenez-Linan,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Margaret Blount,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Miguel Lopez,

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Aline Meirhaeghe,

    Affiliation: INSERM, Institut Pasteur de Lille, Lille Cedex, France

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  • Mohammad Bohlooly-Y,

    Affiliation: AstraZeneca R&D, Mölndal, Sweden

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  • Leonard Storlien,

    Affiliation: AstraZeneca R&D, Mölndal, Sweden

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  • Maria Strömstedt,

    Affiliation: AstraZeneca R&D, Mölndal, Sweden

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  • Michael Snaith,

    Affiliation: AstraZeneca R&D, Mölndal, Sweden

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  • Matej Orešič,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • E. Dale Abel,

    Affiliation: Division of Endocrinology, Metabolism, and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, United States of America

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  • Barbara Cannon,

    Affiliation: The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

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  • Antonio Vidal-Puig mail

    To whom correspondence should be addressed. E-mail: ajv22@cam.ac.uk

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Published: November 07, 2006
  • DOI: 10.1371/journal.pbio.0040369

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PGC-1β: A Regulator of Mitochondrial Function with Subtle Roles in Energy Metabolism

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Synopsis | published 7 Nov 2006 | PLOS Biology
doi:10.1371/journal.pbio.0040402