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Research Article

Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans

  • Matthew V Rockman mail,

    To whom correspondence should be addressed. E-mail: mrockman@princeton.edu

    Affiliation: Department of Biology, Duke University, Durham, North Carolina, United States of America

    ¤a Current address: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

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  • Matthew W Hahn,

    Affiliations: Department of Biology, Duke University, Durham, North Carolina, United States of America, Center for Population Biology, University of California, Davis, California, United States of America

    ¤b Current address: Department of Biology and School of Informatics, Indiana University, Bloomington, Indiana, United States of America

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  • Nicole Soranzo,

    Affiliation: Department of Biology, University College, London, United Kingdom

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  • Fritz Zimprich,

    Affiliation: Department of Clinical Neurology, Medical University of Vienna, Vienna, Austria

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  • David B Goldstein,

    Affiliations: Department of Biology, Duke University, Durham, North Carolina, United States of America, Department of Biology, University College, London, United Kingdom, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Gregory A Wray

    Affiliations: Department of Biology, Duke University, Durham, North Carolina, United States of America, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Published: November 15, 2005
  • DOI: 10.1371/journal.pbio.0030387

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Selection on a Neural Gene Regulator Sheds Light on Human Evolution

Synopsis | published 15 Nov 2005 | PLOS Biology
doi:10.1371/journal.pbio.0030417