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Research Article

Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein

  • Klaus Förstemann,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Yukihide Tomari,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Tingting Du,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Vasily V Vagin,

    Affiliation: Institute of Molecular Genetics of RAS, Moscow, Russia

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  • Ahmet M Denli,

    Affiliation: Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

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  • Diana P Bratu,

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Carla Klattenhoff,

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • William E Theurkauf,

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Phillip D Zamore mail

    To whom correspondence should be addressed. E-mail: phillip.zamore@umassmed.edu

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Published: May 24, 2005
  • DOI: 10.1371/journal.pbio.0030236

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Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells

Kuniaki Saito, Akira Ishizuka, Haruhiko Siomi, Mikiko C Siomi
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miRNA Processing: Dicer-1 Meets Its Match

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doi:10.1371/journal.pbio.0030244