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Research Article

Engineering a Dimeric Caspase-9: A Re-evaluation of the Induced Proximity Model for Caspase Activation

  • Yang Chao equal contributor,

    equal contributor Contributed equally to this work with: Yang Chao, Eric N Shiozaki

    Affiliation: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, United States of America

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  • Eric N Shiozaki equal contributor,

    equal contributor Contributed equally to this work with: Yang Chao, Eric N Shiozaki

    Affiliation: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, United States of America

    X
  • Srinivasa M Srinivasula,

    Affiliation: Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Daniel J Rigotti,

    Affiliation: Department of Biology, Haverford College, Haverford, Pennsylvania, United States of America

    X
  • Robert Fairman,

    Affiliation: Department of Biology, Haverford College, Haverford, Pennsylvania, United States of America

    X
  • Yigong Shi mail

    To whom correspondence should be addressed. E-mail: yshi@molbio.princeton.edu

    Affiliation: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, United States of America

    X
  • Published: May 10, 2005
  • DOI: 10.1371/journal.pbio.0030183

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Linked Articles

Proximity- or Conformation-Induced Caspase Activation?

Synopsis | published 10 May 2005 | PLOS Biology
doi:10.1371/journal.pbio.0030198