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Research Article

PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

  • Teresa C Leone,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • John J Lehman,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Brian N Finck,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Paul J Schaeffer,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Adam R Wende,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Sihem Boudina,

    Affiliation: Program in Human Molecular Biology and Genetics, Division of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah, United States of America

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  • Michael Courtois,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • David F Wozniak,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Nandakumar Sambandam,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Carlos Bernal-Mizrachi,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Zhouji Chen,

    Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • John O. Holloszy,

    Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Denis M Medeiros,

    Affiliation: Department of Human Nutrition, Kansas State University, Manhattan, Kansas, United States of America

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  • Robert E Schmidt,

    Affiliation: Department of Pathology, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Jeffrey E Saffitz,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Pathology, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • E. Dale Abel,

    Affiliation: Program in Human Molecular Biology and Genetics, Division of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah, United States of America

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  • Clay F Semenkovich,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Daniel P Kelly mail

    To whom correspondence should be addressed. E-mail: dkelly@im.wustl.edu

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Published: March 15, 2005
  • DOI: 10.1371/journal.pbio.0030101

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A New Role for a Protein Involved in Energy Metabolism

Synopsis | published 15 Mar 2005 | PLOS Biology
doi:10.1371/journal.pbio.0030133