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Research Article

pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia

  • Karl Simin,

    Affiliation: Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Hua Wu,

    Affiliation: Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    ¤Current address: Phenomix Corporation, La Jolla, California, United States of America

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  • Lucy Lu,

    Affiliation: Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Dan Pinkel,

    Affiliation: Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, United States of America

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  • Donna Albertson,

    Affiliation: Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, United States of America

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  • Robert D Cardiff,

    Affiliation: Center for Comparative Medicine, University of California, Davis, Davis, California, United States of America

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  • Terry Van Dyke mail

    To whom correspondence should be addressed. E-mail: tvdlab@med.unc.edu

    Affiliation: Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Published: February 17, 2004
  • DOI: 10.1371/journal.pbio.0020022

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Synopsis | published 17 Feb 2004 | PLOS Biology
doi:10.1371/journal.pbio.0020059