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Research Article

Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection

  • Laura Papagno,

    Affiliations: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom, Institute of Infectious and Tropical Diseases, University of Milan, L. Sacco Hospital, Milan, Italy

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  • Celsa A Spina,

    Affiliation: San Diego Veterans Affairs Research Center for AIDS and HIV Infection, University of California, San Diego, La Jolla, California

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  • Arnaud Marchant,

    Affiliation: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Mariolina Salio,

    Affiliation: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Nathalie Rufer,

    Affiliation: National Center of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland

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  • Susan Little,

    Affiliation: San Diego Veterans Affairs Research Center for AIDS and HIV Infection, University of California, San Diego, La Jolla, California

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  • Tao Dong,

    Affiliation: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Gillian Chesney,

    Affiliation: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Anele Waters,

    Affiliation: Department of HIV/GUM, The Guy's, Kings', and St Thomas' School of Medicine, London, United Kingdom

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  • Philippa Easterbrook,

    Affiliation: Department of HIV/GUM, The Guy's, Kings', and St Thomas' School of Medicine, London, United Kingdom

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  • P. Rod Dunbar,

    Affiliation: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Dawn Shepherd,

    Affiliation: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Vincenzo Cerundolo,

    Affiliation: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Vincent Emery,

    Affiliation: Department of Virology, Royal Free and University College Medical School, London, United Kingdom

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  • Paul Griffiths,

    Affiliation: Department of Virology, Royal Free and University College Medical School, London, United Kingdom

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  • Christopher Conlon,

    Affiliation: Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Andrew J McMichael,

    Affiliation: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Douglas D Richman,

    Affiliation: San Diego Veterans Affairs Research Center for AIDS and HIV Infection, University of California, San Diego, La Jolla, California

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  • Sarah L Rowland-Jones,

    Affiliation: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Victor Appay

    Affiliation: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Published: February 17, 2004
  • DOI: 10.1371/journal.pbio.0020020

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Linked Articles

T-Cell Differentiation and Progression of HIV Infection

Synopsis | published 17 Feb 2004 | PLOS Biology
doi:10.1371/journal.pbio.0020041