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Research Article

A Force-Activated Trip Switch Triggers Rapid Dissociation of a Colicin from Its Immunity Protein

  • Oliver E. Farrance,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

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  • Eleanore Hann,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

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  • Renata Kaminska,

    Affiliation: Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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  • Nicholas G. Housden,

    Affiliation: Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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  • Sasha R. Derrington,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

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  • Colin Kleanthous,

    Affiliation: Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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  • Sheena E. Radford,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

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  • David J. Brockwell mail

    d.j.brockwell@leeds.ac.uk

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

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  • Published: February 19, 2013
  • DOI: 10.1371/journal.pbio.1001489

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