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Research Article

Inherent Dynamics of the Acid-Sensing Ion Channel 1 Correlates with the Gating Mechanism

  • Huaiyu Yang equal contributor,

    equal contributor Contributed equally to this work with: Huaiyu Yang, Ye Yu

    Affiliation: Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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  • Ye Yu equal contributor,

    equal contributor Contributed equally to this work with: Huaiyu Yang, Ye Yu

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Wei-Guang Li,

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Fang Yu,

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Hui Cao,

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Tian-Le Xu mail,

    tlxu@ion.ac.cn (T-LX); hljiang@mail.shcnc.ac.cn (HJ)

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Hualiang Jiang mail

    tlxu@ion.ac.cn (T-LX); hljiang@mail.shcnc.ac.cn (HJ)

    Affiliations: Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, School of Pharmacy, East China University of Science and Technology, Shanghai, China

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  • Published: July 14, 2009
  • DOI: 10.1371/journal.pbio.1000151

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