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Research Article

MYRF Is a Membrane-Associated Transcription Factor That Autoproteolytically Cleaves to Directly Activate Myelin Genes

  • Helena Bujalka equal contributor,

    equal contributor Contributed equally to this work with: Helena Bujalka, Matthias Koenning

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Matthias Koenning equal contributor,

    equal contributor Contributed equally to this work with: Helena Bujalka, Matthias Koenning

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Stacey Jackson,

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Victoria M. Perreau,

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Bernard Pope,

    Affiliation: Department of Computing and Information Systems and Victorian Life Sciences Computation Initiative (VLSCI), University of Melbourne, Parkville, Australia

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  • Curtis M. Hay,

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Stanlislaw Mitew,

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Andrew F. Hill,

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia

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  • Q. Richard Lu,

    Affiliation: Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas at Austin, Austin, Texas, United States of America

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  • Michael Wegner,

    Affiliation: Institute for Biochemistry, University Erlangen-Nuernberg, Germany

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  • Rajini Srinivasan,

    Affiliation: Waisman Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • John Svaren,

    Affiliation: Waisman Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • Melanie Willingham,

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Ben A. Barres,

    Affiliation: Department of Neurobiology, Stanford University, Stanford, California, United States of America

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  • Ben Emery mail

    emeryb@unimelb.edu.au

    Affiliations: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia, Florey Institute of Neuroscience and Mental Health, Parkville, Australia

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  • Published: August 13, 2013
  • DOI: 10.1371/journal.pbio.1001625

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