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Research Article

A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation

  • Smarajit Polley equal contributor,

    equal contributor Contributed equally to this work with: Smarajit Polley, De-Bin Huang, Arthur V. Hauenstein

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • De-Bin Huang equal contributor,

    equal contributor Contributed equally to this work with: Smarajit Polley, De-Bin Huang, Arthur V. Hauenstein

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • Arthur V. Hauenstein equal contributor,

    equal contributor Contributed equally to this work with: Smarajit Polley, De-Bin Huang, Arthur V. Hauenstein

    Affiliation: Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, San Diego, California, United States of America

    X
  • Amanda J. Fusco,

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • Xiangyang Zhong,

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • Don Vu,

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • Bärbel Schröfelbauer,

    Affiliations: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America, Signaling Systems Laboratory, University of California–San Diego, La Jolla, California, United States of America

    X
  • Youngchang Kim,

    Affiliation: Argonne National Laboratory, Argonne, Illinois, United States of America

    X
  • Alexander Hoffmann,

    Affiliations: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America, Signaling Systems Laboratory, University of California–San Diego, La Jolla, California, United States of America

    X
  • Inder M. Verma,

    Affiliation: Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California, United States of America

    X
  • Gourisankar Ghosh mail,

    gghosh@ucsd.edu (GG); thuxford@mail.sdsu.edu (TH)

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • Tom Huxford mail

    gghosh@ucsd.edu (GG); thuxford@mail.sdsu.edu (TH)

    Affiliation: Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, San Diego, California, United States of America

    X
  • Published: June 11, 2013
  • DOI: 10.1371/journal.pbio.1001581

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