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Research Article

Reconstruction of Ancestral Metabolic Enzymes Reveals Molecular Mechanisms Underlying Evolutionary Innovation through Gene Duplication

  • Karin Voordeckers equal contributor,

    equal contributor Contributed equally to this work with: Karin Voordeckers, Chris A. Brown

    Affiliations: VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium

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  • Chris A. Brown equal contributor,

    equal contributor Contributed equally to this work with: Karin Voordeckers, Chris A. Brown

    Affiliations: VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium, Fathom Information Design, Boston, Massachusetts, United States of America, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America

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  • Kevin Vanneste,

    Affiliations: VIB Department of Plant Systems Biology, Gent, Belgium, Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium

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  • Elisa van der Zande,

    Affiliations: VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium

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  • Arnout Voet,

    Affiliation: Laboratory for Molecular en Structural Biology, KU Leuven, Leuven, Belgium

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  • Steven Maere mail,

    Steven.Maere@psb.vib-ugent.be (SM); Kevin.Verstrepen@biw.vib-kuleuven.be (KJV)

    Affiliations: VIB Department of Plant Systems Biology, Gent, Belgium, Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium

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  • Kevin J. Verstrepen mail

    Steven.Maere@psb.vib-ugent.be (SM); Kevin.Verstrepen@biw.vib-kuleuven.be (KJV)

    Affiliations: VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium

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  • Published: December 11, 2012
  • DOI: 10.1371/journal.pbio.1001446

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