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Research Article

Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans

  • Kirsi H. Pietiläinen equal contributor,

    equal contributor Contributed equally to this work with: Kirsi H. Pietiläinen, Tomasz Róg, Tuulikki Seppänen-Laakso, Sam Virtue

    Affiliations: Department of Medicine, Division of Internal Medicine, and Department of Psychiatry, Obesity Research Unit, Helsinki University Central Hospital, Helsinki, Finland, Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland, Institute for Molecular Medicine Finland, Helsinki, Finland

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  • Tomasz Róg equal contributor,

    equal contributor Contributed equally to this work with: Kirsi H. Pietiläinen, Tomasz Róg, Tuulikki Seppänen-Laakso, Sam Virtue

    Affiliation: Department of Physics, Tampere University of Technology, Tampere, Finland

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  • Tuulikki Seppänen-Laakso equal contributor,

    equal contributor Contributed equally to this work with: Kirsi H. Pietiläinen, Tomasz Róg, Tuulikki Seppänen-Laakso, Sam Virtue

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Sam Virtue equal contributor,

    equal contributor Contributed equally to this work with: Kirsi H. Pietiläinen, Tomasz Róg, Tuulikki Seppänen-Laakso, Sam Virtue

    Affiliation: Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Peddinti Gopalacharyulu,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Jing Tang,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Sergio Rodriguez-Cuenca,

    Affiliation: Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Arkadiusz Maciejewski,

    Affiliations: Department of Physics, Tampere University of Technology, Tampere, Finland, Department of Computational Biophysics and Bioinformatics, Jagiellonian University, Kraków, Poland

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  • Jussi Naukkarinen,

    Affiliations: Department of Medical Genetics, University of Helsinki, Helsinki, Finland, Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland

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  • Anna-Liisa Ruskeepää,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Perttu S. Niemelä,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Laxman Yetukuri,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Chong Yew Tan,

    Affiliation: Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Vidya Velagapudi,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Sandra Castillo,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Heli Nygren,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Tuulia Hyötyläinen,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Aila Rissanen,

    Affiliation: Department of Medicine, Division of Internal Medicine, and Department of Psychiatry, Obesity Research Unit, Helsinki University Central Hospital, Helsinki, Finland

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  • Jaakko Kaprio,

    Affiliations: Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland, Institute for Molecular Medicine Finland, Helsinki, Finland, Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland

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  • Hannele Yki-Järvinen,

    Affiliation: Division of Diabetes, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland

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  • Ilpo Vattulainen,

    Affiliations: Department of Physics, Tampere University of Technology, Tampere, Finland, Department of Applied Physics, School of Science and Technology, Aalto University, Espoo, Finland, MEMPHYS—Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark

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  • Antonio Vidal-Puig,

    Affiliation: Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Matej Orešič mail

    matej.oresic@vtt.fi

    Affiliations: Institute for Molecular Medicine Finland, Helsinki, Finland, VTT Technical Research Centre of Finland, Espoo, Finland

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  • Published: June 07, 2011
  • DOI: 10.1371/journal.pbio.1000623

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