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Research Article

Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

  • Mathieu Blanc,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

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  • Wei Yuan Hsieh,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

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  • Kevin A. Robertson,

    Affiliations: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom, Centre for Systems Biology at Edinburgh, The King's Buildings, Edinburgh, United Kingdom

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  • Steven Watterson,

    Affiliations: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom, Centre for Systems Biology at Edinburgh, The King's Buildings, Edinburgh, United Kingdom

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  • Guanghou Shui,

    Affiliation: Department of Biochemistry and Department of Biological Sciences, National University of Singapore, Singapore

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  • Paul Lacaze,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

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  • Mizanur Khondoker,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

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  • Paul Dickinson,

    Affiliations: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom, Centre for Systems Biology at Edinburgh, The King's Buildings, Edinburgh, United Kingdom

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  • Garwin Sing,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

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  • Sara Rodríguez-Martín,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

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  • Peter Phelan,

    Affiliation: Metabolic Signaling Diseases Program, Sanford-Burnham Medical Research Institute, Orlando, Florida, United States of America

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  • Thorsten Forster,

    Affiliations: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom, Centre for Systems Biology at Edinburgh, The King's Buildings, Edinburgh, United Kingdom

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  • Birgit Strobl,

    Affiliation: Institute of Animal Breeding and Genetics, Veterinary University of Vienna, Vienna, Austria

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  • Matthias Müller,

    Affiliation: Institute of Animal Breeding and Genetics, Veterinary University of Vienna, Vienna, Austria

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  • Rudolph Riemersma,

    Affiliation: Centre for Cardiovascular Disease, University of Edinburgh, Edinburgh, United Kingdom

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  • Timothy Osborne,

    Affiliation: Metabolic Signaling Diseases Program, Sanford-Burnham Medical Research Institute, Orlando, Florida, United States of America

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  • Markus R. Wenk,

    Affiliation: Department of Biochemistry and Department of Biological Sciences, National University of Singapore, Singapore

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  • Ana Angulo,

    Affiliation: Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain

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  • Peter Ghazal mail

    p.ghazal@ed.ac.uk

    Affiliations: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom, Centre for Systems Biology at Edinburgh, The King's Buildings, Edinburgh, United Kingdom

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  • Published: March 08, 2011
  • DOI: 10.1371/journal.pbio.1000598

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