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Research Article

HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer

  • Merel Gijsen,

    Affiliation: Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Peter King,

    Affiliation: Oncology Discovery Research and Early Development, Johnson & Johnson Pharmaceutical Research and Development, Janssen Pharmaceutica, Beerse, Belgium

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  • Tim Perera,

    Affiliation: Oncology Discovery Research and Early Development, Johnson & Johnson Pharmaceutical Research and Development, Janssen Pharmaceutica, Beerse, Belgium

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  • Peter J. Parker,

    Affiliations: Protein Phosphorylation Laboratory, London Research Institute, Cancer Research UK, London, United Kingdom, Division of Cancer Studies, King's College School of Medicine, Guy's Hospital, London, United Kingdom

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  • Adrian L. Harris,

    Affiliation: Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Banafsh√© Larijani,

    Affiliation: Cell Biophysics Laboratory, London Research Institute, Cancer Research UK, London, United Kingdom

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  • Anthony Kong mail

    Anthony.kong@imm.ox.ac.uk

    Affiliation: Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Published: December 21, 2010
  • DOI: 10.1371/journal.pbio.1000563

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