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Research Article

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

  • Christoph Kleinschnitz mail,

    h.schmidt@farmaco.unimaas.nl (HHHWS); christoph.kleinschnitz@mail.uni-wuerzburg.de (CK)

    Affiliation: Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany

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  • Henrike Grund,

    Affiliation: Rudolf-Buchheim-Institut für Pharmakologie & Medizinische Klinik, Justus-Liebig-Universität, Gießen, Germany

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  • Kirstin Wingler,

    Affiliations: Rudolf-Buchheim-Institut für Pharmakologie & Medizinische Klinik, Justus-Liebig-Universität, Gießen, Germany, Department of Pharmacology and Centre for Vascular Health, Monash University, Melbourne, Australia, Department of Pharmacology and Toxicology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands, National Stroke Research Institute, Florey Neuroscience Institutes, Melbourne, Australia

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  • Melanie E. Armitage,

    Affiliations: Department of Pharmacology and Centre for Vascular Health, Monash University, Melbourne, Australia, National Stroke Research Institute, Florey Neuroscience Institutes, Melbourne, Australia

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  • Emma Jones,

    Affiliation: Department of Pharmacology and Centre for Vascular Health, Monash University, Melbourne, Australia

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  • Manish Mittal,

    Affiliation: Rudolf-Buchheim-Institut für Pharmakologie & Medizinische Klinik, Justus-Liebig-Universität, Gießen, Germany

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  • David Barit,

    Affiliation: Baker IDI Heart and Diabetes Institute, Juvenile Diabetes Research Foundation (JDRF) International Center for Diabetic Complications Research, Melbourne, Australia

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  • Tobias Schwarz,

    Affiliation: Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany

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  • Christian Geis,

    Affiliation: Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany

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  • Peter Kraft,

    Affiliation: Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany

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  • Konstanze Barthel,

    Affiliation: Abteilung Neurologie, Georg-August Universität Göttingen, Göttingen, Germany

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  • Michael K. Schuhmann,

    Affiliations: Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany, Universitätsklinik Münster, Klinik und Poliklinik für Neurologie—Entzündliche Erkrankungen des Nervensystems und Neuroonkologie, Münster, Germany

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  • Alexander M. Herrmann,

    Affiliations: Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany, Universitätsklinik Münster, Klinik und Poliklinik für Neurologie—Entzündliche Erkrankungen des Nervensystems und Neuroonkologie, Münster, Germany

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  • Sven G. Meuth,

    Affiliations: Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany, Universitätsklinik Münster, Klinik und Poliklinik für Neurologie—Entzündliche Erkrankungen des Nervensystems und Neuroonkologie, Münster, Germany

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  • Guido Stoll,

    Affiliation: Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany

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  • Sabine Meurer,

    Affiliation: Department of Pharmacology and Centre for Vascular Health, Monash University, Melbourne, Australia

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  • Anja Schrewe,

    Affiliation: Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany

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  • Lore Becker,

    Affiliations: Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany, Friedrich-Baur-Institut an der Neurologischen Klinik, Klinikum der Ludwig-Maximilians-Universität München, München, Germany

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  • Valérie Gailus-Durner,

    Affiliation: Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany

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  • Helmut Fuchs,

    Affiliation: Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany

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  • Thomas Klopstock,

    Affiliation: Friedrich-Baur-Institut an der Neurologischen Klinik, Klinikum der Ludwig-Maximilians-Universität München, München, Germany

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  • Martin Hrabé de Angelis,

    Affiliations: Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany, Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany

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  • Karin Jandeleit-Dahm,

    Affiliation: Baker IDI Heart and Diabetes Institute, Juvenile Diabetes Research Foundation (JDRF) International Center for Diabetic Complications Research, Melbourne, Australia

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  • Ajay M. Shah,

    Affiliation: King's College London School of Medicine, The James Black Centre, Cardiovascular Division, London, United Kingdom

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  • Norbert Weissmann,

    Affiliation: Rudolf-Buchheim-Institut für Pharmakologie & Medizinische Klinik, Justus-Liebig-Universität, Gießen, Germany

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  • Harald H. H. W. Schmidt mail

    h.schmidt@farmaco.unimaas.nl (HHHWS); christoph.kleinschnitz@mail.uni-wuerzburg.de (CK)

    Affiliations: Rudolf-Buchheim-Institut für Pharmakologie & Medizinische Klinik, Justus-Liebig-Universität, Gießen, Germany, Department of Pharmacology and Centre for Vascular Health, Monash University, Melbourne, Australia, Department of Pharmacology and Toxicology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands, National Stroke Research Institute, Florey Neuroscience Institutes, Melbourne, Australia

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  • Published: September 21, 2010
  • DOI: 10.1371/journal.pbio.1000479

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