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Research Article

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

  • Emily S. Sena,

    Affiliations: Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, National Stroke Research Institute, Austin Health, University of Melbourne, Melbourne, Victoria, Australia, Department of Medicine, Austin Health, University of Melbourne, Melbourne, Victoria, Australia

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  • H. Bart van der Worp,

    Affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands

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  • Philip M. W. Bath,

    Affiliation: Stroke Trials Unit, University of Nottingham, Nottingham, England, United Kingdom

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  • David W. Howells,

    Affiliations: National Stroke Research Institute, Austin Health, University of Melbourne, Melbourne, Victoria, Australia, Department of Medicine, Austin Health, University of Melbourne, Melbourne, Victoria, Australia

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  • Malcolm R. Macleod mail

    malcolm.macleod@ed.ac.uk

    Affiliations: Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, Department of Neurology, NHS Forth Valley, Stirling, Scotland, United Kingdom

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  • Published: March 30, 2010
  • DOI: 10.1371/journal.pbio.1000344

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