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Research Article

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

  • Elton Zeqiraj,

    Affiliations: Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, Scotland, MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Beatrice Maria Filippi,

    Affiliation: MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Simon Goldie,

    Affiliations: Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, Scotland, MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Iva Navratilova,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Jérôme Boudeau,

    Affiliation: MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Maria Deak,

    Affiliation: MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Dario R. Alessi,

    Affiliation: MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Daan M. F. van Aalten mail

    dmfvanaalten@dundee.ac.uk

    Affiliation: Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, Scotland

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  • Published: June 09, 2009
  • DOI: 10.1371/journal.pbio.1000126

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