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Research Article

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

  • Jean-Philippe Coppé,

    Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Christopher K Patil equal contributor,

    equal contributor Contributed equally to this work with: Christopher K Patil, Francis Rodier

    Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    X
  • Francis Rodier equal contributor,

    equal contributor Contributed equally to this work with: Christopher K Patil, Francis Rodier

    Affiliations: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Buck Institute for Age Research, Novato, California, United States of America

    X
  • Yu Sun,

    Affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Denise P Muñoz,

    Affiliations: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Buck Institute for Age Research, Novato, California, United States of America

    X
  • Joshua Goldstein,

    Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    ¤ Current address: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Peter S Nelson,

    Affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Pierre-Yves Desprez,

    Affiliations: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, California Pacific Medical Center Research Institute, San Francisco, California, United States of America

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  • Judith Campisi mail

    To whom correspondence should be addressed. E-mail: jcampisi@lbl.gov

    Affiliations: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Buck Institute for Age Research, Novato, California, United States of America

    X
  • Published: December 02, 2008
  • DOI: 10.1371/journal.pbio.0060301

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