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Research Article

Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis

  • Orion D Weiner equal contributor,

    equal contributor Contributed equally to this work with: Orion D Weiner, Maike C Rentel

    Affiliations: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Cardivascular Research Institute, University of California San Francisco, California, United States of America

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  • Maike C Rentel equal contributor,

    equal contributor Contributed equally to this work with: Orion D Weiner, Maike C Rentel

    Affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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  • Alex Ott,

    Affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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  • Glenn E Brown,

    Affiliation: Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Mark Jedrychowski,

    Affiliation: Department of Cell Biology and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Michael B Yaffe,

    Affiliation: Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Steven P Gygi,

    Affiliation: Department of Cell Biology and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Lewis C Cantley,

    Affiliation: Department of Systems Biology, Harvard Medical School, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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  • Henry R Bourne mail,

    To whom correspondence should be addressed. E-mail: bourne@cmp.ucsf.edu (HB), Email: marc@hms.harvard.edu (MK)

    Affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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  • Marc W Kirschner mail

    To whom correspondence should be addressed. E-mail: bourne@cmp.ucsf.edu (HB), Email: marc@hms.harvard.edu (MK)

    Affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: January 24, 2006
  • DOI: 10.1371/journal.pbio.0040038

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