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Research Article

Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway

  • Min Hu,

    Affiliation: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, United States of America

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  • Lichuan Gu,

    Affiliation: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, United States of America

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  • Muyang Li,

    Affiliation: Institute for Cancer Genetics, Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

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  • Philip D Jeffrey,

    Affiliation: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, United States of America

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  • Wei Gu,

    Affiliation: Institute for Cancer Genetics, Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

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  • Yigong Shi mail

    To whom correspondence should be addressed. E-mail: yshi@molbio.princeton.edu

    Affiliation: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, United States of America

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  • Published: January 17, 2006
  • DOI: 10.1371/journal.pbio.0040027

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