08/14/2025
Research Article
Immature neurons have been identified in the adult amygdala of some mammalian species, but their prevalence has not been systematically examined. Marco Ghibaudi, Luca Bonfanti and co-workers characterize amygdalar immature neurons in eight mammalian species, revealing phylogenetic variation and a high prevalence in primates.
Image credit: pbio.3003322
Current Issue July 2025
08/14/2025
Research Article
Plants encounter natural threats of varying intensity and respond by activating multiple defense traits. This study of six defense traits in Ambrosia artemisiifolia, by Jinlong Wan, Wei Huang and co-authors, reveals that when attacked by insect herbivores, less costly traits are induced first, while more costly traits are activated only after higher damage thresholds. Don't miss the accompanying Primer by Ethan Bass.
Image credit: pbio.3003280
08/14/2025
Research Article
How does the brain transfer motor skills between hands? Ali Rezaei, Jason Gallivan and colleagues reveal that transfer relies on re-expressing the neural patterns established during initial learning in distributed higher-order brain areas, offering new insights into learning generalization. Also see the Primer by Hiroshi Imamizu and Toshiyuki Kondo.
Image credit: pbio.3003268
08/14/2025
Research Article
How does the developing immune system learn which microbes to tolerate and which to resist? Burcu Tepekule, Ai Ing Lim and Jessica Metcalf develop a mathematical model of early-life interactions between the gut microbiome and adaptive immunity, showing how maternal antibodies, feeding patterns and microbial ecology shape immune tolerance. Read the Primer by Parsa Ghadermazi and Matthew Olm.
Image credit: pbio.3003263
08/14/2025
Research Article
Archaea regularly interact with bacteria but reports of archaea killing bacteria are very rare. Romain Strock, Tobias Warnecke and co-workers show that many archaea encode peptidoglycan hydrolases, which specifically target bacterial cell walls, and confirm the capacity of two of these enzymes to kill bacteria. See the accompanying Primer by Anna Papageorgiou and Panagiotis Adam
Image credit: pbio.3003235
08/12/2025
Research Article
Intracellular pathogens like Chlamydia trachomatis evade host defenses by preserving vacuole integrity. Using a genome-wide screen, Mohammed Rizwan Babu Sait, Lana Jachmann, Barbara Sixt and co-authors show that the effector CpoS maintains the stability of Chlamydia’s parasitophorous vacuole, and early vacuole destabilization clears infection, highlighting a potential therapeutic target.
Image credit: pbio.3003297
08/11/2025
Essay
This Essay argues that experimental disease ecology can offer powerful tools and approaches to better understand and predict the epidemiological consequences of variable infection history.
Image credit: pbio.3003311
08/01/2025
Perspective
What happens when the greatest strengths of science – openness, humility, self-criticism and self-correction – are exploited for political gain? Brian Nosek calls for scientists to affirm the genuine application of those strengths as the source of its trustworthiness.
Image credit: Pixabay user Geralt
07/29/2025
Editorial
Cancer evolves through dynamic exchanges with its environment. This Editorial by Yibin Kang introduces a new Collection of articles that explore this tumor–environment crosstalk across temporal and spatial scales.
Image credit: Yujiao Han & Yibin Kang
07/28/2025
Perspective
Large-scale omics datasets from tumor samples are becoming ever easier to generate and analyze. This Perspective article looks at how multiomics data be leveraged to help patients in the clinic.
Image credit: PublicDomainPictures from Pixabay
Recent technological advancements in omics have unveiled the mechanisms governing tumor progression across spatial and temporal scales. This collection reveals the complexities of the crosstalk between cancer cells and the tumor microenvironment.
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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August 26 - 30
Meet Senior Editor Richard Hodge (rhodge@plos.org)
September 9 - 12
Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)
September 16 - 19
Meet Editor in Chief Nonia Pariente (npariente@plos.org)
October 5 - 7
Meet Senior Editor Richard Hodge (rhodge@plos.org)
October 7 - 11
Meet Associate Editor Taylor Hart (thart@plos.org)
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