06/20/2025
Research Article
How do T stem cell-like memory (TSCM) cells help to maintain long-term immune memory? Danai Koftori, Charandeep Kaur, Laura Mora Bitria, Becca Asquith and co-workers reveal that human TSCM cells comprise two distinct subpopulations with complementary roles; one supporting clonal longevity and the other driving expansion and self-renewal, together functioning as a stem cell population.
Image credit: pbio.3003179
Current Issue May 2025
06/18/2025
Research Article
Neurons encoding positive or negative prediction errors signal a mismatch between the expected and the experienced input. Amit Yaron, Kenichi Ohki, Hirokazu Takahashi, Zenas Chao and co-authors show how neurons encoding negative prediction errors in the auditory system compute the omission of sounds in a predictable tone sequence.
Image credit: pbio.3003242
06/17/2025
Research Article
Animal development requires egg activation, which is initiated by calcium waves, but the underlying mechanisms remain unclear. Jiajia Ma and Tom Carney show that protease activation of the Par2a receptor on the zebrafish egg surface is required for successful fertilization. Don't miss the accompanying Primer.
Image credit: pbio.3003181
06/16/2025
Research Article
Classical studies suggested that slow amplitude fluctuations in sounds critical for speech recognition are poorly represented in the brainstem. Chris Scholes, Christian Sumner and colleagues show that overlooked intricacies of spike timing represent these fluctuations, reconciling low-level neural processing with perception.
Image credit: pbio.3003213
06/12/2025
Research Article
Conflicting results have been observed regarding changes in synaptic strength in the cerebral cortex during the sleep-wake cycle. This computational study by Fukuaki Kinoshita, Hiroki Ueda and co-workers provides a comprehensive understanding and unified framework about synaptic dynamics during the sleep-wake cycle.
Image credit: pbio.3003198
06/12/2025
Research Article
Epigenetic regulators such as EZH2 are known to be mutated in B cell lymphomas, but the effect of these mutations remains unclear. Ofir Griess, Guy Ron, Efrat Shema and co-authors uncover a role for mutant EZH2 in lymphomagenesis, also establishing a new method for measuring epigenetic heterogeneity and intra-chromatin connectivity in cancer cells. Also see the related Primer by Daniel Holoch and Raphaël Margueron.
Image credit: pbio.3003191
06/20/2025
Perspective
Educational equity faces renewed threats across higher education in the United States. This Perspective addresses what can be done by life science instructors and researchers to prioritize equitable, evidence-based teaching for all.
Image credit: Unsplash user Sam Balye
06/16/2025
Perspective
Functional MRI has been invaluable in understanding brain function. This Perspective explores how neuroimaging in more naturalistic environments may reveal crucial insights into human cognition and social interactions in everyday life.
Image credit: pbio.3003210
06/11/2025
Essay
The relationship between migraine aura and headache has been the subject of a long-standing debate. This Essay delves into the mechanistic and pathophysiological links between migraine aura and headache.
Image credit: pbio.3003168
06/10/2025
Perspective
Can AI become a true scientist? Nina Miolane explores how new technologies are reshaping scientific discovery, and why human expertise remains essential as we enter a new era of research powered by intelligent algorithms.
Image credit: pbio.3003230
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
June 22 - 27
Meet Editor in Chief Nonia Pariente (npariente@plos.org)
June 24 - 27
Meet Associate Editor Melissa Vazquez Hernandez (mvazquezhernandez@plos.org)
June 30 - July 2
Meet Senior Editor Roli Roberts (rroberts@plos.org)
July 8 - 9
Meet Senior Editor Christian Schnell (cschnell@plos.org)
July 13 - 17
Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)
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