06/05/2025
Short Report
Androgen receptor-positive prostate cancer cells abundantly express hormone-dependent tRNA halves, but their functions are unclear. Takuya Kawamura, Megumi Shigematsu and Yohei Kirino show that the 5′-tRNALysCUU half promotes cell cycle progression by destabilizing the mRNA of p21, a negative regulator, suggesting a general role for these molecules.
Image credit: pbio.3003194
Current Issue May 2025
06/05/2025
Short Report
Body ownership disorders can be triggered by disease or body damage in humans. Zineb Hayatou, Luc Estebanez and colleagues show, using an automated, videography-based procedure, that mice also display quantifiable behavioral markers of the embodiment of an artificial limb, opening the door to future research on these disorders.
Image credit: Luc Estebanez
06/05/2025
Research Article
Humans can apply solutions used in past problems to new problems. Sam Hall-McMaster, Momchil Tomov, Samuel Gershman and Nicolas Schuck reveal the neural correlates of this process, known as generalization, and show that humans apply past policies in a reward-sensitive manner that leads to high performance.
Image credit: pbio.3003174
06/04/2025
Research Article
The RNA-binding protein RBM39 has been previously shown to be a target of the anti-cancer agent Indisulam. Tongjia Zhang, Xiaowei Zhang and co-workers show that RBM39 is methylated by PRMT6, which determines the resistance to Indisulam in lung cancer models due to aberrant splicing events.
Image credit: pbio.3002846
06/03/2025
Research Article
What are the molecular targets of inhaled anesthetics like isoflurane? Hiroyuki Kanaya, Ken Kuwajima, Hiroki Ueda and co-authors reveal that isoflurane binds type 1 ryanodine receptor, and show that genetically disrupting a specific residue or pharmacologically activating this binding site with novel agonists can modulate sensitivity to anesthesia.
Image credit: pbio.3003172
06/02/2025
Research Article
Sound-guided prediction of upcoming salient events is important for planning, timing and executing behaviors such as crossing a street or evading predation. Harini Suri, Gideon Rothschild and colleagues identify an auditory cortical-striatal circuit that supports sound-triggered timing-prediction behaviors in mice.
Image credit: pbio.3003209
05/20/2025
Perspective
Increasing concerns over the welfare of captive cetaceans have led to calls for their transfer to sanctuaries. This Perspective describes an unprecedented collaboration to develop the first accreditation guidelines for authentic ocean sanctuaries.
Image credit: pbio.3003166
05/15/2025
Perspective
To what extent can we predict future pathogenic microbes? Arturo Casadevall discusses why complex requirements for virulence and dynamic host-microbe interactions make probabilistic predictions difficult, but not impossible.
Image credit: pbio.3003162
05/07/2025
Consensus View
Vertebrate photoreceptors have been studied for well over a century, but a fixed nomenclature across species has been lacking. This Consensus View proposes a new consolidated and pan-vertebrate naming system for the rod and cone photoreceptors of the eye.
Image credit: pbio.3003157
05/07/2025
Perspective
Interferon is a central component of the vertebrate antiviral response. John Schoggins highlights recent findings that suggest a refined ‘limited set’ model of its activity, in which distinct viruses are targeted by small subsets of the induced gene repertoire.
Image credit: pbio.3003154
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
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Meet Associate Editor Taylor Hart (thart@plos.org)
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Meet remotely Magazine Senior Editor Joanna Clarke (jclarke@plos.org)
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