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Mapping cell identities in relation to neighbors

July 15, 2025

Mapping cell identities in relation to neighbors

Measuring the properties of individual cells in relation to their neighbors in 3D tissues is currently technically challenging. Matthew French, Guillaume Blin, Valerie Wilson, Sally Lowell and colleagues develop a computational toolkit to facilitate this analysis, and demonstrate its utility in analyzing developmental patterning in the mouse, chick and Drosophila embryo.

Image credit: Matthew French

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PLOS BIOLOGUE

07/17/2025

Short Reports

Optimal navigation in penguins

How are magellanic penguins able to navigate tidal currents while balancing energy efficiency and foraging opportunities? Richard Gunner, Rory Wilson and co-workers reveal how penguins adaptively make S-shaped return paths to their colony, optimizing travel in complex oceanic flows.

Image credit: Unsplash user William Warby and pbio.3002981

Optimal navigation in penguins

Recently Published Articles

Current Issue

Current Issue June 2025

07/16/2025

Research Article

Influenza A virus manipulates host membrane dynamics to exit

Influenza A virus (IAV) relies on host proteins to transport its genome from the nucleus to the plasma membrane for the production of new viral particles. Carla Alemany, Juliane Da Graça, Etienne Morel, Jean-Baptiste Brault, Nadia Naffakh and co-authors show that IAV reshapes phosphoinositide metabolism and localization via ATG16L1 to control host membrane dynamics and promote vRNP trafficking.

Image credit: pbio.3002958

Influenza A virus manipulates host membrane dynamics to exit

07/15/2025

Research Article

How musical training keeps aging at bay

Long-term musical training can provide additional neural resources to help cope with the effect of aging. Lei Zhang, Bernhard Ross, Yi Du and Claude Alain describe the neural mechanisms behind this observation, showing that cognitive reserve acquired through long-term music training holds back age-related neural recruitment during speech-in-noise perception.

Image credit: Mohan Yuan

How musical training keeps aging at bay

07/15/2025

Short Reports

Protective synthetic bacterial communities for plants

The plant microbiome can protect its host against detrimental bacterial strains. Anton Amrhein, Kathrin Wippel and colleagues show that competition among Pseudomonas bacteria in synthetic bacterial communities determines how well they can protect Arabidopsis thaliana, and that a single competitive strain within a community can suffice for this.


Protective synthetic bacterial communities for plants

Image credit: pbio.3002882

07/14/2025

Research Article

Prioritizing contents of working memory

Changes in attention flexibly modulate the sensory contents of working memory, but the dynamics of motor contents in working memory are unclear. Irene Echeverria-Altuna, Anna Nobre and co-workers show that brain representations of both sensory and motor contents of working memory are modulated by attentional shifts, and are temporally uncoupled from one another.

Prioritizing contents of working memory

Image credit: pbio.3003273

07/14/2025

Short Reports

A greenhouse trade-off vanishes in the field

In controlled greenhouse conditions, Arabidopsis thaliana plants with a hyperactive allele of the ACD6 gene have stronger pathogen defenses but are smaller and make fewer seeds, in a classic fitness trade-off. Derek Lundberg, Detlef Weigel and co-authors show that in the open field both the advantages and disadvantages of the allele disappear, revealing the dangers of making ecological inferences from lab results.

A greenhouse trade-off vanishes in the field

Image credit: pbio.3003237

07/18/2025

Essay

Multilevel selection in cancer evolution

This Essay examines how selection operates across levels, highlighting how we might leverage this understanding to improve cancer research, prevention and treatment.

Multilevel selection in cancer evolution

Image credit: pbio.3003290

07/15/2025

Essay

How cancer and immune cell plasticity

This Essay explores the mutual plasticity of various cell types in the tumor microenvironment and discusses implications for the development of therapeutic strategies.

How cancer and immune cell plasticity

Image credit: pbio.3003301

07/14/2025

Essay

Single-cell omics to decode metastatic microenvironments 

This Essay explores the use of single-cell technologies in mapping and analyzing metastatic niches, and investigates how to harness insights gained to inform novel therapeutic interventions.

Single-cell omics to decode metastatic microenvironments 

Image credit: pbio.3003299

07/14/2025

Essay

Metabolic reprogramming between cancer cells and T cells

This Essay discusses bi-directional metabolic crosstalk between tumors and T cells, highlighting metabolic targeting as a promising strategy to reprogram anti-tumor immune responses.

Metabolic reprogramming between cancer cells and T cells

Image credit: pbio.3003284

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