07/11/2025
Research Article
Mechanism of haptoglobin–hemoglobin clearance
The CD163 scavenger receptor on macrophages clears free hemoglobin in the bloodstream via binding to the haptoglobin-hemoglobin (HpHb) complex. Ching-Shin Huang, Lidia Mosyak and co-workers solve the cryo-EM structure of CD163 in complex with HpHb and reveal the mechanism by which CD163-mediated endocytosis efficiently clears different isoforms of HpHb.
Image credit: pbio.3003264
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